The digital media are the new interface between mind and world.They enable us to gain instant access to an infinitely expandable collective memory system.This is an indispensable breakthrough, but has the potential to seriously violate the ancient co-evolutionary pact between brain and culture which has kept the rate of cultural and technological c
The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis
As cancer is a multifactorial disease, the multimodal action of microRNAs makes them an attractive tool for novel therapeutic approaches.The tumor suppressive miR-7-5p has been shown to act on many aspects of oncogenesis, including cell proliferation, migration and angiogenesis, by targeting a spectrum of key genes.We developed a synthetic chemical
Effect of Glu12-His89 Interaction on Dynamic Structures in HIV-1 p17 Matrix Protein Elucidated by NMR.
To test the existence of the salt bridge and stability of the HIV-1 p17 matrix protein, an E12A (mutated at helix 1) was established to abolish possible electrostatic interactions.The chemical shift perturbation from the comparison between wild type and E12A suggested the existence of an electrostatic interaction in License Plate Products wild type
Real-Time Operational Research: Case Studies from the Field of Tuberculosis and Lessons Learnt
Real-time operational research can be defined as research on strategies or interventions to assess if they are feasible, working as planned, scalable and effective.The research involves primary data collection, periodic analysis during the conduct of the study and dissemination of the findings to policy makers for timely action.This paper aims to i